61 research outputs found
Peptide size dependent active transport in the proteasome
We investigate the transport of proteins inside the proteasome and propose an
active transport mechanism based on a spatially asymmetric interaction
potential of peptide chains. The transport is driven by fluctuations which are
always present in such systems. We compute the peptide-size dependent transport
rate which is essential for the functioning of the proteasome. In agreement
with recent experiments, varying temperature changes the transport mechanism
qualitatively.Comment: 4 pages, 4 figure
- …